S. pombe genetic interactome

This is a database of conserved functional modules identified using global maps of genetic interactions in S. pombe and S. cerevisiae.
See "Hierarchical Modularity and the Evolution of Genetic Interactomes across Species" by Ryan, Roguev et al for full details.
Clicking on a module ID will provide you with further detail on that module.
Uncharacterized genes have no biological process annotation in Pombase.
Search for genes by typing into the text box below.

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IDEnriched GO termSystematic Gene NamesCommon Gene NamesS. cerevisiae GenesUncharacterised
1Set3 complexSPCC1235.09, SPAC3G9.07C, SPAC22E12.11CHIF2, HOS2, SET3SIF2, HOS2, SET3False
2F-actin capping protein complexSPAC12B10.07, SPAC631.01CACP1, ACP2CAP1, CAP2False
3DNA replication-independent nucleosome assemblySPBC947.08C, SPBC31F10.13CHIP4, HIP1HIR1, HPC2False
4response to acidSPBC119.08, SPAC1F3.02CPMK1, MKH1BCK1, SLT2False
5UnknownSPBC1734.06, SPAC13G6.01CRHP18, RAD8RAD5, RAD18False
6proton-transporting ATP synthase complex biogenesisSPAC3A12.12, SPAC9.12CATP12, ATP11ATP12, ATP11False
7alpha-1,6-mannosyltransferase complexSPBC8D2.17, SPAC637.06SPBC8D2.17, SPAC637.06MNN11, MNN10False
8calcium ion transportSPAC6F6.01, SPAC1F5.08CYAM8, CCH1MID1, CCH1False
9heteroduplex formationSPAC3C7.03C, SPAC644.14C, SPAC20H4.07RHP55, RHP57, RHP51RAD57, RAD55, RAD51False
10UnknownSPBC1773.01, SPBC3H7.13SPBC1773.01, SPBC3H7.13FAR8, FAR10True
11peptidyl-diphthamide biosynthetic process from peptidyl-histidineSPBC3B8.05, SPBC17D1.02SPBC3B8.05, DPH2DPH1, DPH2False
12retromer complexSPCC777.13, SPAPJ696.01C, SPCPJ732.01VPS17, VPS35, VPS5VPS17, VPS35, VPS5False
13UnknownSPBC216.01C, SPBC26H8.05CSPBC216.01C, SPBC26H8.05CPSY2, PPH3False
14cell adhesionSPCC74.03C, SPCC1919.03CSSP2, SPCC1919.03CSNF1, GAL83False
15mitotic anaphaseSPBC1604.20C, SPAC3C7.12TEA2, TIP1KIP2, BIK1False
16CCAAT-binding factor complexSPAC23C11.08, SPBC3B8.02PHP5, PHP3HAP5, HAP3False
17UnknownSPBC31F10.12, SPBC16C6.05SPBC31F10.12, SPBC16C6.05TMA20, TMA22False
18protein targeting to peroxisomeSPAC17C9.14, SPBC725.07, SPCC553.03PEX1, SPAC17C9.14, PEX5PEX1, PEX19, PEX5False
19dolichol-linked oligosaccharide biosynthetic processSPBC56F2.10C, SPAC56F8.06C, SPBC1734.12C, SPAC1834.05, SPBC342.01C, SPAC17C9.07ALG8, ALG9, ALG6, ALG5, ALG10, ALG12ALG8, ALG9, DIE2, ALG6, ALG5, ALG12False
20transcriptionally active chromatinSPBC2A9.11C, SPAC1B3.08SPBC2A9.11C, SPAC1B3.08CSN12, YPR045CFalse
21protein import into peroxisome matrixSPAC3C7.10, SPBC17A3.10PAS4, PEX13PEX10, PEX13False
22pyridoxine biosynthetic processSPAC222.08C, SPAC29B12.04SNZ1, SPAC222.08CSNZ1, SNO1False
23small ribosomal subunitSPAC13G6.02C, SPCC285.15CRPS101, RPS2802RPS1A, RPS28B, RPS28AFalse
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decaySPAC16C9.06C, SPBC2F12.03C, SPAC13G7.03UPF1, SPBC2F12.03C, UPF3EBS1, UPF3, NAM7True
25vacuole inheritanceSPBC4F6.10, SPCC364.05VPS3, VPS901VPS3, VPS9False
26Rpd3L complexSPBC1685.08, SPBC1709.11C, SPBC21C3.02C, SPBC428.06CCTI6, PNG2, RXT2, DEP1CTI6, DEP1, PHO23, RXT2False
27mitotic cell cycle spindle assembly checkpointSPBC20F10.06, SPCC1795.01C, SPBC3D6.04C, SPAC23H3.08CMAD2, MAD3, BUB3, MAD1MAD2, MAD3, BUB3, MAD1False
28endosome membraneSPBC4B4.06, SPAC11H11.01, SPAC19A8.05C, SPBC215.14CVPS20, SST6, SST4, VPS25STP22, VPS25, VPS20, VPS27False
29prefoldin complexSPAC227.05, SPAC3A11.13, SPBC215.02, SPAC3H8.07CSPAC227.05, SPAC3A11.13, PAC10, BOB1YKE2, GIM5, GIM3, PAC10False
30NuA3 histone acetyltransferase complexSPAC17G8.13C, SPBC17D11.04CNTO1, MST2NTO1, SAS3False
31histone methylationSPAC22F8.12C, SPBC354.03, SPCC18.11C, SPBC13G1.08C, SPAC23H3.05C, SPCC594.05CSPF1, SDC1, SHF1, SWD3, ASH2, SWD1SDC1, SWD3, LGE1, SPP1, BRE2, SWD1False
32DNA damage checkpointSPAC14C4.13, SPAC1952.07, SPAC20G4.04C, SPBC342.05, SPAC664.07CHUS1, RAD17, RAD9, RAD1, CRB2MEC3, RAD17, RAD24, DDC1, RAD9False
33Swr1 complexSPCC576.13, SPCC550.12, SPAC631.02, SPBP35G2.13C, SPBC11B10.10C, SPAC11E3.01C, SPAC4H3.02CPHT1, SWC5, SWC3, SPAC631.02, SWC2, ARP6, SWR1SWC5, SWC3, HTZ1, BDF2, ARP6, SWR1, VPS72False
34UnknownSPCC16C4.01, SPAC12G12.15SIF2, SIF3RMD1, RMD8False
35UnknownSPBC530.01, SPBC23E6.08, SPAC4C5.02CGYP1, RYH1, SAT1GYP1, RGP1, YPT6False
36Atg1p signaling complexSPAC4F10.07C, SPCC63.08CATG13, ATG1ATG1, ATG13False
37UnknownSPCC4B3.16, SPAC4F10.04SPAC4F10.04, TIP41RRD1, TIP41False
38UnknownSPAC6B12.05C, SPAC23G3.04IES4, IES2IES4, IES2False
39maintenance of rDNASPAC18G6.10, SPCC4G3.11HEH1, MUG154NUR1, SRC1True
40NDC1 complexSPBC29A10.07, SPAC1002.02SPBC29A10.07, MUG31POM34, POM152False
41Rpd3S complexSPAC23H4.12, SPAC2F7.07C, SPAC16C9.05, SPAC23C11.15CPH1, PST2, ALP13, CPH2EAF3, RCO1, SIN3False
42UnknownSPAC227.17C, SPAC4G8.11CSPAC227.17C, ATP10EMI1, ATP10True
43UnknownSPBC3E7.05C, SPBC25H2.09SPBC3E7.05C, SPBC25H2.09FCJ1, AIM13True
44mitotic sister chromatid cohesionSPAC31A2.15C, SPAC3G6.11, SPAPB1E7.02CCHL1, MCL1, DCC1CHL1, CTF4, DCC1False
45UnknownSPBC1198.06C, SPBC16G5.09SPBC1198.06C, SPBC16G5.09KEX1, DFG5False
46UnknownSPAC6G9.09C, SPCC330.14CRPL24, RPL2402RPL24B, RPL24AFalse
47DNA replication-dependent nucleosome assemblySPAC26H5.03, SPAC25H1.06PCF3, PCF2MSI1, CAC2False
48UnknownSPAC6G9.08, SPBC887.04CLUB1, UBP6DOA1, UBP6False
49Ski complexSPBC32F12.02, SPCC1919.05REC14, SPCC1919.05SKI8, SKI3False
50protein phosphatase type 2A complexSPBC16H5.07C, SPAC1782.05PPA2, SPAC1782.05PPH21, RRD2False
51tRNA wobble uridine modificationSPAC29A4.20, SPAC30.02C, SPAC2G11.10C, SPBC36.07, SPCC895.06, SPBC3H7.10, SPBC19C2.13C, SPBC2G5.03SPAC30.02C, SPAC2G11.10C, ELP3, CTU2, SPCC895.06, SPBC3H7.10, IKI3, CTU1IKI3, NCS6, KTI12, UBA4, NCS2, ELP6, ELP3, ELP2False
52UnknownSPCC777.04, SPCC191.09CSPCC777.04, GST1URE2, GNP1False
53DUBm complexSPAC13A11.04C, SPCC126.04CUBP8, SGF73UBP8, SGF73False
54ribosome disassemblySPCC18B5.06, SPBC25B2.01SPCC18B5.06, SPBC25B2.01HBS1, DOM34False
55UnknownSPAC1687.05, SPCC338.16PLI1, POF3NFI1, DIA2False
56RAVE complexSPBC1105.10, SPBC3H7.12RAV1, RAV2RAV1, RAV2False
57AP-3 adaptor complexSPAC144.06, SPCC594.06C, SPBC651.11C, SPAC23H3.06SPCC594.06C, APM3, APL6, APL5APM3, APL6, APL5, VAM7False
58UnknownSPAC17A5.16, SPAC31A2.14FTP105, BUN107YOL087C, ECM30False
59UnknownSPBC947.09, SPBC1921.05APE2, SPBC947.09APE2, SNO4False
60UnknownSPAC23C4.03, SPAC2C4.16CHRK1, RPS801ALK2, RPS8AFalse
61UnknownSPBC119.12, SPAC4G8.10, SPAC227.01CSPBC119.12, GOS1, SPAC227.01CRUD3, GOS1, ERD1False
62UnknownSPBC947.10, SPAC1486.02C, SPCC285.11, SPAC20H4.02UCP10, DSC2, DSC3, DSC1TUL1, UBX3, YOL073C, YOR223WTrue
63endoplasmic reticulum palmitoyltransferase complexSPBC3H7.09, SPAC3F10.07CMUG142, MUG91SHR5, ERF2False
64UnknownSPCC70.03C, SPCC1223.03CSPCC70.03C, GUT2GUT2, PUT1False
65UnknownSPAC8E11.07C, SPBC336.14CALP31, PPK26PAN3, RBL2False
66mitochondrial large ribosomal subunitSPBC4F6.08C, SPAC1610.02CSPAC1610.02C, MRPL39MRPL1, MRPL39False
67UnknownSPBC2F12.13, SPBC1685.15C, SPBC4C3.12SEP1, KLP5, KLP6HCM1, KIP3False
68UnknownSPBC36B7.05C, SPBC582.08SPBC36B7.05C, SPBC582.08ALT2, PIB1False
69histone H3-K79 methylationSPAC1834.03C, SPBC8D2.03CHHF2, HHF1HHF2, HHF1False
70septin checkpointSPAC644.06C, SPAC57A10.02CDR2, CDR1HSL1, GIN4False
71UnknownSPBC21C3.01C, SPAC824.02VPS13A, SPAC824.02BST1, VPS13False
72UnknownSPCC4B3.02C, SPBC25H2.14SPCC4B3.02C, MUG16GOT1, GMH1False
73eukaryotic translation elongation factor 1 complexSPCC794.09C, SPAC13G7.02CSSA1, EF1A-ASSA1, TEF2, TEF1False
74UnknownSPAC3G9.11C, SPAC167.04SPAC3G9.11C, PAM17THI3, PAM17False
75gene silencing involved in chronological cell agingSPCC188.07, SPCC16C4.20C, SPBC800.03CCQ1, CLR3, SPCC16C4.20CHDA3, HDA1, NHP10False
76GID complexSPAC12B10.13, SPAC26H5.04SPAC12B10.13, SPAC26H5.04VID28, GID8False
77manganese ion transportSPAC27F1.08, SPBC31E1.02CPMR1, PDT1SMF2, PMR1False
78UnknownSPAC1A6.03C, SPAC11E3.13CSPAC1A6.03C, GAS5GAS5, PLB3False
79UnknownSPCC306.02C, SPBC660.14SPCC306.02C, MIK1SWE1, YIP3False
80UnknownSPCC162.12, SPAC15F9.02SEH1, TCO89SEH1, TCO89False
81UnknownSPAC16A10.04, SPAC2E1P3.02CAMT3, RHO4MEP1, RHO4False
82phospholipid translocationSPBC11B10.07C, SPAC24B11.12CSPAC24B11.12C, IVN1LEM3, DNF2False
83carboxy-terminal domain protein kinase complexSPCC4B3.08, SPAC1D4.06C, SPAC2F3.15CSK1, LSG1, LSK1CTK1, CTK3False
84UnknownSPCC320.03, SPBC215.01SPCC320.03, SPBC215.01RGT1, MDR1False
85UnknownSPAC11E3.04C, SPAC29B12.06CUBC13, RCD1UBC13, CAF40False
86spindleSPAC18G6.15, SPAPB1A10.09, SPAC3A11.14CASE1, PKL1, MAL3KAR3, ASE1, BIM1False
87pre-autophagosomal structure membraneSPBC4B4.10C, SPBC15D4.07CATG9, ATG5ATG9, ATG5False
88negative regulation of kinase activitySPCC24B10.13, SPBC1685.01PMP1, SKB5MSG5, NBP2True
89regulation of transposition, RNA-mediatedSPCC338.08, SPBC582.05C, SPAC3H8.05C, SPBC342.06CCTP1, BRC1, MMS1, RTT109RTT109, SAE2, MMS1, RTT107False
90NLS-bearing substrate import into nucleusSPAC1805.04, SPAC19E9.01CNUP40, NUP132NUP53, NUP133, ASM4False
91transcription elongation from RNA polymerase II promoterSPAC20H4.03C, SPBC13E7.08CTFS1, SPBC13E7.08CLEO1, DST1False
92UnknownSPAC2F7.04, SPAC17G6.08PMC2, PEP7MED1, PEP7False
93global genome nucleotide-excision repairSPAC1834.04, SPBC8D2.04, SPBC1105.11CHHT1, HHT2, HHT3HHT1, HHT2False
94UnknownSPAC767.01C, SPCC162.06C, SPAC22E12.05CSPCC162.06C, VPS1, RER1VPS1, RER1, VPS60False
95UnknownSPAC869.05C, SPBP4G3.02PHO1, SPAC869.05CPHO3, SUL1True
96UnknownSPBC27.06C, SPAC9E9.09C, SPAC6B12.12MGR2, SPAC9E9.09C, TOM70MGR2, ALD6, TOM70True
97UnknownSPCC1450.06C, SPBC359.05GRX3, ABC3GRX6, BPT1False
98cytosolic large ribosomal subunitSPBC685.07C, SPAC959.08, SPAC4G9.16C, SPBP8B7.06, SPCC364.03, SPBC83.02C, SPAC3G9.03, SPCC1223.05CRPL2701, RPL1702, RPL4302, RPL2301, RPL3702, RPP201, RPL2102, RPL901RPL37B, RPL37A, RPL23A, RPL17B, RPL27B, RPL9A, RPL9B, RPL43B, RPP2A, RPP2B, RPL21BFalse
99UnknownSPBC713.03, SPAC9E9.03SPBC713.03, LEU2DLD2, LEU1False
100UnknownSPBC3E7.12C, SPAC9G1.05SPAC9G1.05, CHR1SHC1, AIP1False
101UnknownSPBC3D6.05, SPAC222.14CPTP4, SPAC222.14CSEY1, DGK1False
102UnknownSPCC16A11.07, SPAC22F3.06CLON1, COQ10COQ10, PIM1False
103UnknownSPBC17D11.08, SPAC26F1.01SPBC17D11.08, SEC74SYT1, YPL247CFalse
104UnknownSPAC1565.01, SPAC17H9.12CSPAC1565.01, SPAC17H9.12CAIM38, CYC2True
105small ribosomal subunitSPAC144.11, SPBC16D10.11C, SPAC23C11.02C, SPBC839.13C, SPAC959.07, SPAC664.04C, SPBC685.06, SPBC19F8.08, SPBP16F5.05C, SPAC31G5.17C, SPAC1952.02RPS23, RPS401, RPL1601, RPS403, RPS001, RPS1001, SPBP16F5.05C, RPS1801, RPS1102, SPAC1952.02, RPS1602RPS4B, RPS16B, RPS23A, YAR1, RPS16A, RPL16A, RPS18B, RPS11B, RPS10B, TMA23, RPS0A, RPS0BFalse